Value of Fresh Amniotic Membrane Graft in Management of Resistant Non Infected Corneal Ulcer

Current medical treatments of non infected resistant corneal ulcer include topical artificial tears, lubricants [1] and experimental trials of fibronectin [2], insulin-like growth factor type I [3] and substance P [3], autologous serum [4] or nerve growth factor [5]. When these medical therapies fail, one may consider patching, scleral contact lens, cyanoacrylate glue [6], conjunctival flap, tarsorrhaphy or penetrating keratoplasty [7]. Recently, amniotic membrane transplantation (AMT) has been successfully used to treat persistent corneal epithelial defects and ulcers from different causes and for corneal and conjunctival surface reconstruction for a variety of ocular surface disorders [8].